CIDER: Classification of Intrinsically Disordered Ensemble Regions

Classification of Intrinsically Disordered Regions and Proteins

Robin van der Lee,*,†,‡ Marija Buljan,†,▲ Benjamin Lang,†,▲ Robert J. Weatheritt,†,▲ Gary W. Daughdrill, A. Keith Dunker, Monika Fuxreiter, Julian Gough, Joerg Gsponer, David T. Jones, Philip M. Kim, Richard W. Kriwacki, Christopher J. Oldfield, Rohit V. Pappu, Peter Tompa, Vladimir N. Uversky, Peter E. Wright, and M. Madan Babu*,† †MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cam...

Multi-scale ensemble modeling of modular proteins with intrinsically disordered linker regions: application to p53.

In eukaryotic proteins, intrinsically disordered regions (IDRs) are ubiquitous and often exist in linker regions that flank the functional domains of modular proteins, regulating their functions. For detailed structural ensemble modeling of IDRs, we propose a multiscale method for IDRs that possess significant long-range order in modular proteins and apply it to the eukaryotic transcription fac...

Testing the validity of ensemble descriptions of intrinsically disordered proteins.

Describing sequence-ensemble relationships for intrinsically disordered proteins.

Intrinsically disordered proteins participate in important protein-protein and protein-nucleic acid interactions and control cellular phenotypes through their prominence as dynamic organizers of transcriptional, post-transcriptional and signalling networks. These proteins challenge the tenets of the structure-function paradigm and their functional mechanisms remain a mystery given that they fai...

Analysis of structured and intrinsically disordered regions of transmembrane proteins.

Integral membrane proteins display two major types of transmembrane structure, helical bundles and beta barrels. The main functional roles of transmembrane proteins are the transport of small molecules and cell signaling, and sometimes these two roles are coupled. For cytosolic, water-soluble proteins, signaling and regulatory functions are often carried out by intrinsically disordered regions....